Bioinformatics

I long had an interest in finding a way to connect my mathematics research with molecular biology. I was not able to do this, but in the attempt, I had some interesting experiences.

In the summer of 1998, I worked part-time for Dr. Bill Gmeiner, a researcher in the Epply Cancer Institute at the University of Nebraska Medical Center (UNMC). The major focus of his laboratory was determining the structure and dynamics of DNA, RNA, and proteins using NMR spectroscopy and molecular modeling. Although, I was not there long enough to make a real contribution to Dr. Gmeiner's lab, I gained some intution about the methods scientists use in analysing both the static and dynmaic structure of proteins.

 

A year after I retired from full-time teaching, I met Dr. Simon Sherman, the director of the newly established Nebraska Informatics Center for the Life Sciences and began working with him on a consulting basis. Soon I became the coordinator of the Center.

During my almost three years with Dr. Sherman, I learned a lot about how to run a Center. See my article: Checklists of some of the Activities of a Center, PDF file.

I also gave a couple of guest lectures in the UNMC Genetic Sequence Analysis Course. The power point files for my lectures are accessible below:

The Computer Science, Mathematical and Statistical Basic for Sequence Alignment

Hidden Markov Models with Applications to Sequence Alignment


Research Contacts